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Rani, Smitha
- Formulation and Standardization of Polyherbal Antihyperlipidemic Formulation
Abstract Views :130 |
PDF Views:77
Authors
S. L. Manju
1,
Smitha Rani
2
Affiliations
1 Department of Chemistry, School of Advanced Sciences, VIT University, Vellore – 632014, Tamil Nadu, IN
2 Department of Chemistry, VIT University, Vellore – 632014, Tamil Nadu, IN
1 Department of Chemistry, School of Advanced Sciences, VIT University, Vellore – 632014, Tamil Nadu, IN
2 Department of Chemistry, VIT University, Vellore – 632014, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 20, No 4 (2020), Pagination: 228-239Abstract
Hyperlipidemia is a very common medical condition. A fairly less invasive, more effective and efficient method with lower or no side effects to treat Hyperlipidemia are to be developed. Thus, use of traditional herbal medication can be a relevant solution to it. Development of highly standardized Polyherbal formulation with respect to chemical content and therapeutic activity is considered as a valuable approach in the field of herbal industry. Traditional medicine is known for its Polyherbal contents and multicomponent therapeutics for managing health problems. Thus, the present research is focused on to formulate, standardize a polyherbal medicine to treat hyperlipidemia and also compared its chemical contents based on, geographical, seasonal variations using standard physio-chemical parameters such as Ash values, Extractive values, pH, and loss on drying, Particle size analysis and physical analysis of powder formulation. HPTLC fingerprinting, with markers such as Gallic acid, Quercetin, Gymnemic acid, and Mahanine were carried out. In addition, residue analysis such as heavy metal content, microbial load, pesticide analysis, aflotoxin determination were also carried out to strengthen the standardization process and to ensure safety.Keywords
Antihyperlipidemic, HPTLC Profiling, Physico-chemical Parameters, Polyherbal, StandardizationFull Text
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- HPLC Quantification and Stability Study of Antilipidemic Polyherbal Formulation
Abstract Views :165 |
PDF Views:77
Authors
Smitha Rani
1,
S. L. Manju
1
Affiliations
1 Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore – 632 014, Tamil Nadu, IN
1 Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore – 632 014, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 380 - 392Abstract
Hyperlipidemia is one of the major risk factor for cardio vascular disorders, which accounts for the one third of total death in the world. In the present study an Antilipidemic polyherbal formulation was prepared and contains four herbal drugs namely Murraya koenigi leaves, Acacia catechu bark, Emblica officinalis fruits and leaves of Gymnema sylvestra. The study involved HPLC marker-based quantification and shelf-life evaluation of a traditional Antilipidemic formulation. The quantification method for the biomarkers present in the polyherbal formulation was developed using reverse phase method by using shim-pack HPLC C18 column (250 X 4.6 mm, 5 μm). The four phytoconstituents selected for the study are mahanine, quercetin, gallic acid and gymnemic acid respectively. The percentage content of quercetin, gallic acid, gymnemic acid and mahanine in the PHF was found to be 0.82%w/w,10.15%w/w, 2.77%w/w and 14.19%w/w respectively. Shelf life is an important component that is mandatory to be displayed on the label of all medicinal products. This is also applicable to Ayurveda. The shelf life of polyherbal formulations is also assessed in this study using an accelerated stability analysis. At a temperature of 40.2 °C and a relative humidity of 75%, physicochemical parameters were measured. The analysis was repeated at 1, 3, and 6-month intervals, with the average 10% deterioration time calculated and extrapolated to determine the shelf life. It was found that the shelf life of formulated Antilipidemic polyherbal formulation was 2 years 2 months. The polyherbal formulation prepared and evaluated can be effectively used for the treatment of hyperlipidemia and the preparation can be used without any deterioration for a period of 2 years.
Keywords
Hyperlipidaemia, HPLC Quantification, Polyherbal Formulation, Shelf-life Study.Full Text
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